Hairy cell leaukemia

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Hairy cell leukemia HCL is a rare type of blood cancer characterized by abnormal changes in white blood cells known as B lymphocytes. The bone marrow creates too many of these defective cells, known as "hairy cells" because of the thin hair-like projections found on their surface. Overproduction and accumulation of hairy cells causes a deficiency of normal blood cells pancytopeniaincluding an abnormal decrease of certain white blood cells neutrophils [neutropenia] and certain red blood cells platelets [thrombocytopenia].

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Back to Health A to Z. It's not known what causes hairy cell leukaemia. The condition most commonly affects people aged and is more common in men than women.

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Home Blood cancer information Leukaemia Hairy cell leukaemia Hairy cell leukaemia treatment Side effects of hairy cell leukaemia treatment. Listen All treatments can cause side effects. However, the type and severity will vary between individuals, depending on the type of treatment used and how an individual responds to it.

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Hairy cell leukemia HCL is an uncommon type of lymphocytic leukemia that starts in B cells, or B lymphocytes a type of white blood cell. It is called hairy cell leukemia because hair-like projections can be seen on the surface of the cancer cells when they are viewed under a microscope. It is more common in men than in women. The average age at diagnosis is 50 years.

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Hairy cell leukemia HCL is a unique chronic lymphoproliferative disorder that can mimic or coexist with other clonal hematologic disorders and has been associated with autoimmune disorders. It should be entertained as an alternative diagnosis in patients with cytopenias being assigned the diagnosis of aplastic anemia, hypoplastic myelodysplastic syndrome, atypical chronic lymphocytic leukemia, B-prolymphocytic leukemia, or idiopathic myelofibrosis. Causative etiology or molecular defects remain unclear, although nonspecific chromosomal and molecular changes have been described.

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Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoid myelofibrosis in publications dating back to the s. The disease was formally named leukemic reticuloendotheliosis and its characterization significantly advanced by Bertha Bouroncle and colleagues at The Ohio State University College of Medicine in

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The DNA genetic material of a developing stem cell in the bone marrow is damaged. As a result, the number of healthy blood cells red cells, white cells and platelets is usually lower than normal. Doctors don't know why some cells become hairy cells and others don't.

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Hairy cell leukemia HCL is a rare type of blood and bone marrow cancer that affects your B lymphocytes, which are white blood cells that make antibodies to fight infections. These abnormal cells can take up the space of healthy B lymphocytes, which can weaken your immune system and make you susceptible to infections. HCL gets its name because the abnormal white blood cells look hairy under a microscope.

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It depends on your individual condition, treatment and level of fitness. Statistics for this type of leukaemia are harder to estimate than for other, more common leukaemias. Some of the statistics have to be based on a small number of people. Remember, they can't tell you what will happen in your individual case.

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